JOHN J. MARINI, MD, Director of physiological and translational research, Regions Hospital

HealthPartners Medical Group title: Physician in pulmonary medicine, Regions Hospital.

 

Education: MD, Johns Hopkins University School of Medicine; residency in internal medicine and fellowship in pulmonary medicine, University of Washington.

 

Research highlights: : Cardiopulmonary interactions, dynamic hyperinflation, mathematical modeling of respiratory mechanics, modes of ventilation, patient-ventilator interactions, the work of breathing during mechanical ventilation, tracheal gas insufflation, and airway bio-fluids, propagation of lung injury, and pathobiology of ventilator-induced lung injury. Investigative methodology has ranged from highly theoretical mathematical models of invasive and non-invasive mechanical ventilation and gas exchange through bench laboratory testing to laboratory research using small and large animal models of acute lung injury and therapeutic practices. He has also engaged in physiologic investigations involving normal subjects and chronically ill patients, and has helped to develop techniques for improving diagnostic ability at the bedside (e.g., in monitoring and weaning assessment) as well as to implement therapeutic techniques of value to the critically ill patient.

 

Research interests/expertise: Cardiopulmonary physiology and management of acute respiratory failure, with an emphasis on patient-ventilator interactions occurring in that clinical setting. In most of his research, he has positioned himself at the interface between basic physiology and clinical medicine to develop insights into advancing clinical practice.

 

Current projects: Collaborating with colleagues who are well-versed in advanced imaging and biological sciences to explore questions of mutual interest.