John J. Marini, MD

Director of Physiological & Translational Research, Regions Hospital
Professor of Medicine, University of Minnesota

Research Interests

Dr. Marini's investigative work has concentrated in the cardiopulmonary physiology and management of acute respiratory failure, with an emphasis on patient-ventilator interactions occurring in that clinical setting. In the majority of his research, he has positioned himself at the interface between basic physiology and clinical medicine so as to develop insights into advancing clinical practice. General areas of investigation have included cardio-pulmonary interactions; dynamic hyperinflation; mathematical modeling of respiratory mechanics; modes of ventilation; patient-ventilator interactions; work-of-breathing during mechanical ventilation; tracheal gas insufflation; and, most recently, airway bio-fluids, propagation of lung injury, and pathobiology of ventilator-induced lung injury. Investigative methodology has ranged from highly theoretical mathematical models of invasive and non-invasive mechanical ventilation and gas exchange through bench laboratory testing, to laboratory research using small and large animal models of acute lung injury and therapeutic practices. Currently he is collaborating with colleagues who are well versed in advanced imaging and biological sciences to explore questions of mutual interest. Outside the bench lab setting, he has also engaged in physiologic investigations involving normal subjects and chronically ill patients, and has helped to develop techniques for improving diagnostic ability at the bedside (e.g., in monitoring and weaning assessment) as well as to implement therapeutic techniques of value to the critically ill patient.

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